https://www.ibiology.org/microbiology/virus-structures/#part-3
Harrison begins his talk by asking why most non-enveloped infections and some enveloped infections are symmetrical in shape. This arrangement results in symmetrically formed viruses.
In Part 1, Harrison also describes that enveloped viruses contaminate cells by inducing the combination of the viral and host cell membranes. He dives much deeper into the molecular mechanism of membrane combination driven by the hemagglutinin or HA protein of the influenza infection in Part 2 of his talk.
Non-enveloped infections, on the other hand, should go into cells by a mechanism other than membrane combination. This is the focus of Part 3. Using rotavirus as a design, Harrison and his coworkers have utilized a mix of Xray crystallography and electron cryomicroscopy to understand how the spike protein on the viral surface area alters its conformation and perforates the cell membrane enabling the infection to get in the cell.
https://xraytechniciancertification.org/stephen-harrison-harvard-part-3-non-enveloped-infection-entry/
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